Protease Inhibitors and Phosphatase Inhibitors
Selleck Chemical LLC Motesanib Diphosphate (AMG-706) 10mg 857876-30-3
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit (c-Kit), ~10-fold more selective for VEGFR than PDGFR and Ret. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical BCATc InhIbItr 2 50mg
A sulfonyl hydrazide that inhibits BCATc (IC50s = 0.81 and 0.2 µM in human and rat, respectively) with 15-fold selectivity over BCATm; blocks calcium influx into neurons (IC50 = 4.8 µM) following inhibition of glutamate uptake and demonstrates neuroprotective efficacy in vivo
CPC Scientific Ac-Tyr-Val-Ala-Asp-CMK 0.5MG
Irreversible inhibitor of caspase-1 (ICE) that has also been shown to be a potent therapeutic agent against in vivo liver apoptosis in mice.ONE-LETTER SEQUENCE: Ac-YVAD-CMKMOLECULAR FORMULA: C24H33N4O8Cl1MOLECULAR WEIGHT:541STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [178603-78-6], RESEARCH AREA: ApoptosisREFERENCES: J. B. Schulz et al., J Neurosci, 16, 4696 (1996); N.P.C. Walker et al., Cell 78, 343 (1994)
CPC Scientific Boc-Asp(OBzl)-CMK 1MG
Inhibitor that penetrates cells and binds covalently to the active site of caspase-1 (ICE). At a concentration of 2.5 ?M, it blocks caspase-1-mediated processing of mature interleukin-1beta in a monocytic cell line by 85% without influencing tumor necrosis factor processing. ONE-LETTER SEQUENCE: Boc-D(OBzl)-CMKMOLECULAR FORMULA: C17H22Cl1NO5MOLECULAR WEIGHT:355.8STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [172702-58-8], RESEARCH AREA: ApoptosisREFERENCES: N.Boudreau et al., Science, 267, 891 (1995)
Cayman Chemical CathepsIn L InhIbItr 25mg
A potent cathepsin L inhibitor (IC50 = 0.85 nM); selective for cathepsin L over calpain II and cathepsin B (IC50s = 184, and 85.1 nM, respectively); trypanocidal against T. brucei (ED50 = 45 nM); completely suppresses osteoclastic pit formation on femur slices isolated from bovine cortical bone at a concentration of 1 μg/ml; inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner
Cayman Chemical Aurora A InhIbItr I 1mg
A potent and selective inhibitor of Aurora A kinase (IC50s = 3.4 and 3,400 nM for Aurora A and Aurora B, respectively); prevents centrosome separation and reduces phosphorylated Aurora A, but not phosphorylated histone H3, levels at the centrosomes; reduces the proliferation of HCT116 and HT-29 colorectal carcinoma cells in vitro (IC50s = 0.19 and 2.9 μM, respectively)
Medchemexpress LLC Boc-Pro-prolinal | 86925-97-5 | MFCD00890691 | 98.3% | 296.36 g/mol | C15H24N2O4 | 5 MG
Prolyl endopeptidase inhibitor 1 (Boc-Pro-prolinal) is a small-molecule inhibitor of prolyl endopeptidase (PEP) used in biochemical and pharmacological research. It displays high affinity (Ki = 15 nM) and has reported anti-amnesic effects in preclinical studies. The compound is supplied as a solid and as DMSO stock solutions, with recommended storage at -20°C for solid material and -80°C for long-term solvent stocks.
- High potency against prolyl endopeptidase (Ki = 15 nM).
- High purity (98.34%).
- Available as solid and as DMSO stock solutions.
- Supplied in research-scale quantities suitable for in vitro and preclinical studies.
- Storage instructions provided for solid and solvent formats.
American Research Products Inc XANTHINE OXIDASE XOD INHIBITOR
5000265406 XANTHINE OXIDASE XOD INHIBITOR
Cayman Chemical PTP InhIbItr II 25g
A cell-permeable inhibitor of the catalytic domain of SHP-1, SHP-1(ΔSH2) (Ki = 128 µM)
Cayman Chemical NFATc1 InhIbItr A04 10mg
An NFATc1 inhibitor; inhibits RANKL-induced nuclear translocation of NFATc1 in RAW 264.7 cells at 1.5 or 2 µM; reduces RANKL-induced differentiation of RAW 264.7 cells into osteoclasts (IC50 = 1.57 µM)
Cayman Chemical ALK5 InhIbItr II 5mg
A selective inhibitor of the TGF-β type1 receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively); used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription
Cayman Chemical CathepsIn G InhIbItr I 500ug
A cathepsin G inhibitor (IC50 = 53 nM); selective for cathepsin G over thrombin, Factor Xa, Factor IXa, plasmin, trypsin, and PR3 (IC50s = >100 µM for all), but also weakly inhibits chymotrypsin; inhibits cathepsin G-induced activation of IL-36 in neutrophil degranulates at 10 µM; reduces CD4+ T cell-induced secretion of IFN-γ and IL-17 in B cells incubated with TTC and also reduces TTC presentation in B cells at 10 µM; decreases the size of neuromyelitis optica lesions and reduces the number of perivascular neutrophils when used in combination with sivelestat in a mouse model of IgG-induced brain injury at 5 UG/animal
Cayman Chemical PD-1PD-L1 InhIbItr 1 5mg
A PD-1/PD-L1 interaction inhibitor; inhibits the PD-1/PD-L1 interaction in a TR-FRET assay (IC50 = 6-100 nM); reduces LPS-induced increases in PD-1 levels and apoptosis in MH-S mouse alveolar macrophages at 1 µM; surgical neointimal patching with PD-1/PD-L1-coated patches decreases neointimal thickness and inflammatory cell accumulation in a rat model of patch angioplasty
Cayman Chemical PTP InhIbItr III 1mg
A photoreversible covalent inhibitor of PTPs; binds the catalytic domain of SHP-1 (Ki = 184 µM) and covalently reacts with free thiols, a reaction that is reversible with irradiation (350 nm)
Gold Biotechnology Inc AEBSF 5 g
AEBSF is an irreversible serine protease inhibitor. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin, kallikrein and thrombin. It inhibits by acylation of the active site of the enzyme. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25mM. Aqueous solutions are stable between pH 5-6; limited stability above pH 7.5.